Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 18/20 | 0.49 |
| ▸ | EP300 | Q09472 | 2/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538102 | 0.89 | BRD4 (0.47) | SLC6A2SLC6A4SLC6A3BRD4EP300 | |
| SCHEMBL15539253 | 0.87 | BRD4 (0.61) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15538634 | 0.82 | BRD4 (0.62) | BRD4BRD2SMARCA2BRD3BRDT | |
| SCHEMBL15540256 | 0.79 | BRD4 (0.50) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15538914 | 0.79 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3BRD4EP300 | |
| SCHEMBL16654654 | 0.79 | BRD4 (0.62) | BRD4EP300 | |
| SCHEMBL15538776 | 0.78 | BRD4 (0.60) | BRD4BRD2SMARCA2BRD3BRDT | |
| SCHEMBL15539864 | 0.77 | BRD4 (0.49) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15538750 | 0.77 | BRD4 (0.50) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15539399 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3BRD4KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | claimed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | claimed |
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | disclosed |