Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.56 |
| ▸ | EP300 | Q09472 | 4/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538092 | 0.89 | BRD4 (0.65) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15540255 | 0.84 | BRD4 (0.51) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15540131 | 0.84 | BRD4 (0.51) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15537716 | 0.83 | BRD4 (0.52) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15541612 | 0.83 | BRD4 (0.62) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15538083 | 0.83 | BRD4 (0.62) | BRD4EP300 | |
| SCHEMBL15537932 | 0.82 | BRD4 (0.48) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15537533 | 0.82 | BRD4 (0.48) | BRD4EP300BRD2SMARCA2BRD3 | |
| SCHEMBL15541159 | 0.81 | BRD4 (0.62) | BRD4EP300 | |
| SCHEMBL15538914 | 0.80 | SLC6A2 (0.54) | BRD4EP300BRD2SMARCA2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | claimed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | claimed |
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | disclosed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | disclosed |