Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.75 |
| ▸ | BRD2 | P25440 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | TSPO | P30536 | 1/20 | 0.55 |
| ▸ | EP300 | Q09472 | 1/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15539767 | 0.93 | BRD4 (0.81) | BRD4BRD2ADORA2BTSPOEP300 | |
| SCHEMBL20135830 | 0.89 | BRD4 (0.70) | BRD4 | |
| SCHEMBL15541486 | 0.89 | BRD4 (0.75) | BRD4BRD2ADORA2BTSPOEP300 | |
| SCHEMBL15539424 | 0.88 | BRD4 (0.73) | BRD4 | |
| SCHEMBL15551534 | 0.86 | BRD4 (0.68) | BRD4 | |
| SCHEMBL15539146 | 0.86 | BRD4 (1.00) | BRD4 | |
| SCHEMBL15538566 | 0.85 | BRD4 (1.00) | BRD4BRD2ADORA2BTSPOEP300 | |
| SCHEMBL15537548 | 0.84 | BRD4 (0.86) | BRD4BRD2ADORA2BTSPOEP300 | |
| SCHEMBL15540657 | 0.83 | BRD4 (0.83) | BRD4BRD2ADORA2BTSPOEP300 | |
| SCHEMBL15537395 | 0.83 | BRD4 (1.00) | BRD4BRD2ADORA2BTSPOEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858990-B1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC (US) | 2018-05-16 | — | — | EP | claimed |
| US-9561231-B2 | Pyridinone and pyridazinone derivatives | ABBVIE INC. (US) | 2017-02-07 | — | — | US | claimed |
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | claimed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | claimed |
| EP-2858990-B1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC (US) | 2018-05-16 | — | — | EP | disclosed |
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | disclosed |