Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.46 |
| ▸ | MOK | Q9UQ07 | 6/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15544105 | 0.89 | FASN (0.49) | FASNHSD11B1MCHR1AXLMERTK | |
| SCHEMBL15544244 | 0.88 | FASN (0.49) | FASNHSD11B1AXLMERTKNPY5R | |
| SCHEMBL15543524 | 0.88 | FASN (0.49) | FASNHSD11B1AXLMERTK | |
| SCHEMBL15543780 | 0.88 | FASN (0.51) | FASNHSD11B1NPY5R | |
| SCHEMBL15543588 | 0.87 | FASN (0.48) | FASNHSD11B1MCHR1AXLMERTK | |
| SCHEMBL15543457 | 0.86 | FASN (0.49) | FASNHSD11B1AXLMERTK | |
| SCHEMBL15543128 | 0.86 | FASN (0.48) | FASNMOKHSD11B1 | |
| SCHEMBL15543479 | 0.85 | FASN (0.48) | FASNHSD11B1 | |
| SCHEMBL15543784 | 0.84 | FASN (0.50) | FASNHSD11B1 | |
| SCHEMBL14842076 | 0.83 | FASN (0.65) | FASNHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |