Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 14/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15544096 | 0.83 | CFTR (0.38) | SLC6A3PDK2PDK4CFTRSCN9A | |
| SCHEMBL24746179 | 0.82 | SOS1 (0.40) | SLC6A3PDK2PDK4CFTRSCN9A | |
| SCHEMBL16759241 | 0.81 | TSHR (0.41) | SLC6A3PDK2PDK4SCN9ASCN5A | |
| SCHEMBL10148394 | 0.79 | NOTUM (0.40) | SCN9ANOTUMALDH1A1HPGD | |
| SCHEMBL31432451 | 0.78 | GAA (0.41) | SLC6A3PDK2PDK4CFTRSCN9A | |
| SCHEMBL12487977 | 0.78 | PDK2 (0.38) | SLC6A3PDK2PDK4ALDH1A1HPGD | |
| SCHEMBL31460077 | 0.77 | MAPK1 (0.45) | SCN9ANOTUMALDH1A1HPGD | |
| SCHEMBL31502284 | 0.76 | PDK2 (0.40) | SLC6A3PDK2PDK4CFTRSCN9A | |
| SCHEMBL21232435 | 0.76 | CFTR (0.49) | SLC6A3PDK2PDK4CFTRSCN9A | |
| SCHEMBL24928666 | 0.76 | KDM4E (0.41) | SLC6A3PDK2PDK4CFTRSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870138-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |