Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 7/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543513 | 0.91 | FASN (0.46) | FASNEGLN1OPRM1SIGMAR1ROCK2 | |
| SCHEMBL15544232 | 0.86 | FASN (0.46) | FASNEGLN1OPRM1SIGMAR1ROCK2 | |
| SCHEMBL15544184 | 0.86 | FASN (0.46) | FASNEGLN1OPRM1SIGMAR1ROCK2 | |
| SCHEMBL15543586 | 0.85 | FASN (0.63) | FASNEGLN1OPRM1SIGMAR1ROCK2 | |
| SCHEMBL15581976 | 0.81 | FASN (0.44) | FASNEGLN1OPRM1SIGMAR1ROCK2 | |
| SCHEMBL14720295 | 0.81 | FASN (0.43) | FASNMETGSK3B | |
| Hydrochloric Acid SCHEMBL15543580 | 0.80 | FASN (0.44) | FASNEGLN1OPRM1SIGMAR1ROCK2 | |
| SCHEMBL4534412 | 0.79 | FASN (0.70) | FASNGSK3B | |
| SCHEMBL15543899 | 0.79 | FASN (0.47) | FASNEGLN1OPRM1SIGMAR1CHRM1 | |
| SCHEMBL15544453 | 0.76 | FASN (0.41) | FASNEGLN1OPRM1SIGMAR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |