Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.67 |
| ▸ | BRAF | P15056 | 9/20 | 0.60 |
| ▸ | RAF1 | P04049 | 7/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | FRK | P42685 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167964 | 0.87 | KDR (0.68) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL5319531 | 0.86 | KDR (0.67) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL26155567 | 0.86 | KDR (0.67) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL177735 | 0.86 | KDR (0.67) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL16651380 | 0.86 | KDR (0.67) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL18681347 | 0.85 | BRAF (0.70) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL13603818 | 0.84 | KDR (0.65) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL3590776 | 0.84 | BRAF (0.69) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL19149350 | 0.84 | KDR (0.58) | KDRBRAFRAF1EPHX2PLK4 | |
| SCHEMBL257980 | 0.83 | RAF1 (0.82) | KDRBRAFRAF1EPHX2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922820-A1 | PROCESS FOR PREPARING CRYSTALLINE SORAFENIB TOSYLATE | Shilpa Medicare Limited (IN) | 2015-09-30 | — | — | EP | disclosed |
| WO-2013175483-A1 | PROCESS FOR PREPARING CRYSTALLINE SORAFENIB TOSYLATE | SHILPA MEDICARE LIMITED (IN) | 2013-11-28 | — | — | WO | disclosed |