Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 16/20 | 0.42 |
| ▸ | PIM1 | P11309 | 15/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 15/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15546221 | 1.00 | PIM3 (0.42) | PIM3PIM1PIM2MAP4K1 | |
| SCHEMBL15589070 | 0.88 | PIM1 (0.40) | PIM3PIM1PIM2 | |
| SCHEMBL16587828 | 0.83 | PIM3 (0.41) | PIM3PIM1PIM2 | |
| SCHEMBL15818304 | 0.81 | PIM1 (0.45) | PIM3PIM1PIM2 | |
| SCHEMBL17272982 | 0.81 | PIM1 (0.45) | PIM3PIM1PIM2 | |
| SCHEMBL15818305 | 0.81 | PIM1 (0.45) | PIM3PIM1PIM2 | |
| SCHEMBL17272981 | 0.81 | PIM1 (0.45) | PIM3PIM1PIM2 | |
| SCHEMBL16698700 | 0.81 | PIM2 (0.51) | PIM3PIM1PIM2 | |
| SCHEMBL16698701 | 0.81 | PIM2 (0.51) | PIM3PIM1PIM2 | |
| SCHEMBL15817952 | 0.79 | PIM1 (0.44) | PIM3PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2874987-A1 | alpha-AND gamma-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF | The Research Foundation Of State University Of New York (US) | 2015-05-27 | — | — | EP | disclosed |
| EP-2861585-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2014015276-A1 | α-AND γ-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2014-01-23 | — | — | WO | disclosed |
| WO-2013175388-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |