Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.42 |
| ▸ | PIM1 | P11309 | 11/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16698848 | 1.00 | PIM2 (0.42) | PIM2PIM1PIM3CYP3A4CYP2D6 | |
| SCHEMBL16698846 | 1.00 | PIM2 (0.42) | PIM2PIM1PIM3CYP3A4CYP2D6 | |
| SCHEMBL15588722 | 0.84 | PIM1 (0.39) | PIM2PIM1PIM3MAP4K1 | |
| SCHEMBL15588724 | 0.84 | PIM1 (0.39) | PIM2PIM1PIM3MAP4K1 | |
| SCHEMBL16587843 | 0.84 | PIM2 (0.41) | PIM2PIM1PIM3CYP3A4CYP2D6 | |
| SCHEMBL16505911 | 0.84 | CYP3A4 (0.42) | PIM2PIM1PIM3CYP3A4CYP2D6 | |
| SCHEMBL16505912 | 0.84 | CYP3A4 (0.42) | PIM2PIM1PIM3CYP3A4CYP2D6 | |
| SCHEMBL15546743 | 0.79 | PIM2 (0.46) | PIM2PIM1PIM3CYP3A4CYP2D6 | |
| SCHEMBL15546741 | 0.77 | PIM2 (0.44) | PIM2PIM1PIM3 | |
| SCHEMBL3223208 | 0.75 | PIM1 (0.41) | PIM2PIM1PIM3GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861585-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013175388-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |