Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 19/20 | 0.69 |
| ▸ | TNKS2 | Q9H2K2 | 19/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15547901 | 1.00 | TNKS (0.69) | TNKSTNKS2CYP2C9CYP2C19C5AR1 | |
| SCHEMBL15535472 | 0.89 | TNKS (0.87) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15548367 | 0.89 | TNKS (0.87) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15547009 | 0.88 | TNKS (0.64) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15547007 | 0.88 | TNKS (0.64) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15547166 | 0.82 | TNKS (0.83) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15547983 | 0.82 | TNKS (0.83) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15560925 | 0.82 | TNKS (1.00) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15560927 | 0.82 | TNKS (1.00) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15547980 | 0.82 | TNKS (0.83) | TNKSTNKS2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177349-A2 | QUINAZOLINEDIONES AS TANKYRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |