Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 18/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15547623 | 0.90 | TNKS (0.60) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15534447 | 0.87 | TNKS (0.78) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15534448 | 0.87 | TNKS (0.78) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15548882 | 0.83 | TNKS (0.76) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15546933 | 0.83 | TNKS (0.75) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15548393 | 0.81 | TNKS (0.76) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15536214 | 0.77 | TNKS (0.81) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15536219 | 0.77 | TNKS (0.81) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15548238 | 0.75 | TNKS (0.81) | TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL15535608 | 0.75 | TNKS (0.81) | TNKSTNKS2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177349-A2 | QUINAZOLINEDIONES AS TANKYRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |