SCHEMBL15548501

SCHEMBL15548501

Cc1cnc(-c2ccc(C3(C(N)=O)CC3c3ccccc3)cc2)nc1

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 15/20 0.49
CHRM1 P11229 1/20 0.42
HDAC3 O15379 2/20 0.37
HDAC1 Q13547 2/20 0.37
HDAC7 Q8WUI4 2/20 0.37
HDAC8 Q9BY41 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
HDAC9 Q9UKV0 2/20 0.37
HDAC5 Q9UQL6 2/20 0.37
NCOR2 Q9Y618 2/20 0.37
KDM1A O60341 2/20 0.34
MAOA P21397 2/20 0.34
MAOB P27338 2/20 0.34
OPRL1 P41146 1/20 0.34
DHODH Q02127 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6628664 0.79 CHRM1 (0.56) CHRM1KDM1AMAOAMAOB
SCHEMBL15772757 0.75 HDAC4 (0.66) HDAC4HDAC3HDAC1HDAC7HDAC8
SCHEMBL6259044 0.74 CHRM1 (0.43) HDAC4CHRM1KDM1AMAOAMAOB
SCHEMBL6259049 0.71 CHRM1 (0.43) HDAC4CHRM1KDM1AMAOAMAOB
SCHEMBL15549047 0.70 HDAC4 (0.55) HDAC4HDAC3HDAC1HDAC7HDAC8
SCHEMBL12498065 0.69 HDAC4 (0.77) HDAC4HDAC3HDAC1HDAC7HDAC8
SCHEMBL15557808 0.69 HDAC4 (0.77) HDAC4HDAC3HDAC1HDAC7HDAC8
SCHEMBL15548495 0.69 HDAC4 (0.77) HDAC4HDAC3HDAC1HDAC7HDAC8
SCHEMBL15754675 0.67 CHRM1 (0.59) CHRM1KDM1AMAOAMAOB
SCHEMBL19145660 0.67 MKNK1 (0.53) HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2871955-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI Foundation, Inc. (US) 2015-05-20 EP disclosed
WO-2014014900-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. (US) 2014-01-23 WO disclosed