Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712181 | 0.85 | NR1H4 (0.50) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL23927631 | 0.84 | RARB (0.51) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL10476041 | 0.84 | RARB (0.59) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL31568856 | 0.82 | RARB (0.50) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL1020426 | 0.82 | RARB (0.50) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL5097471 | 0.82 | RARB (0.50) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL15548440 | 0.82 | RARB (0.54) | RARBNR1H4PPARARXRAHMGB1 | |
| SCHEMBL16899346 | 0.82 | FFAR4 (0.54) | RARBNR1H4 | |
| SCHEMBL14312369 | 0.82 | RARB (0.54) | RARBNR1H4PPARARXRALCK | |
| SCHEMBL107902 | 0.81 | HMGB1 (0.58) | RARBNR1H4RXRAHMGB1CXCL12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875003-B1 | NEW 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS UND THEIR USE | Bayer Pharma AG (DE) | 2016-11-16 | — | — | EP | disclosed |
| EP-2875003-A1 | NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014012934-A1 | NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-01-23 | — | — | WO | disclosed |