Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUBP1 | Q96AE4 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20509002 | 0.85 | MAPT (0.55) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL17481124 | 0.78 | HPGD (0.66) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL21945591 | 0.78 | MAPT (0.53) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL22628220 | 0.78 | MAPT (0.53) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL19750283 | 0.78 | MAPT (0.53) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL19750268 | 0.78 | MAPT (0.53) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL17066247 | 0.72 | MAPT (1.00) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL4203865 | 0.72 | MAPT (1.00) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL17066232 | 0.72 | MAPT (0.73) | FUBP1MAPTTP53TDP1TSHR | |
| SCHEMBL21945408 | 0.71 | FUBP1 (0.79) | FUBP1MAPTTP53TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855476-A2 | TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013181579-A2 | TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2013-12-05 | — | — | WO | disclosed |