Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 15/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15552317 | 0.86 | BRD4 (0.54) | BRD4 | |
| SCHEMBL15551492 | 0.84 | BRD4 (0.54) | BRD4SOS1CREBBP | |
| SCHEMBL15550298 | 0.83 | BRD4 (0.46) | BRD4 | |
| SCHEMBL15554200 | 0.83 | BRD4 (0.53) | BRD4CREBBP | |
| SCHEMBL15538643 | 0.81 | BRD4 (0.63) | BRD4 | |
| SCHEMBL15550954 | 0.81 | BRD4 (0.71) | BRD4CREBBP | |
| SCHEMBL15549841 | 0.81 | BRD4 (0.51) | BRD4SOS1 | |
| SCHEMBL15549928 | 0.81 | BRD4 (0.53) | BRD4 | |
| SCHEMBL15551540 | 0.81 | BRD4 (0.51) | BRD4SOS1 | |
| SCHEMBL15551236 | 0.79 | BRD4 (0.57) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | disclosed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | disclosed |