SCHEMBL15550902

SCHEMBL15550902

COc1cc(Nc2nc(-c3ccc4c(c3)C(=O)NCCO4)cn3ccnc23)ccc1N1CCOC(CO)C1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 20/20 0.57
CD63 P08962 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15550900 1.00 SYK (0.57) SYKCD63
SCHEMBL2546112 0.92 SYK (0.70) SYKCD63
SCHEMBL2479321 0.92 SYK (0.70) SYKCD63
SCHEMBL15551262 0.86 SYK (0.57) SYKCD63
SCHEMBL15551264 0.86 SYK (0.57) SYKCD63
SCHEMBL2475574 0.84 SYK (0.79) SYK
SCHEMBL2480361 0.84 SYK (0.79) SYK
SCHEMBL18455067 0.83 SYK (0.56) SYKCD63
SCHEMBL2480849 0.83 SYK (0.60) SYKCD63
SCHEMBL13337852 0.83 SYK (0.56) SYKCD63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013188856-A1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2013-12-19 WO disclosed