Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 17/20 | 0.60 |
| ▸ | ACE | P12821 | 8/20 | 0.53 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19600285 | 1.00 | MME (0.60) | MMEACEMMEL1TAAR1 | |
| SCHEMBL15467558 | 1.00 | MME (0.60) | MMEACEMMEL1TAAR1 | |
| SCHEMBL19605644 | 0.91 | MME (0.52) | MMEACEMMEL1TAAR1 | |
| SCHEMBL20376145 | 0.91 | MME (0.52) | MMEACEMMEL1TAAR1 | |
| SCHEMBL11969583 | 0.88 | MME (0.64) | MMEACE | |
| SCHEMBL12481241 | 0.88 | MME (0.64) | MMEACE | |
| SCHEMBL12481247 | 0.88 | MME (0.64) | MMEACE | |
| SCHEMBL12481244 | 0.88 | MME (0.64) | MMEACE | |
| SCHEMBL22414048 | 0.87 | MME (0.50) | MMEACEMMEL1 | |
| SCHEMBL22414044 | 0.87 | MME (0.50) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964616-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2882716-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014138053-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2014025891-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2014-02-13 | — | — | WO | disclosed |