Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.55 |
| ▸ | ACE | P12821 | 4/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15467595 | 1.00 | MME (0.55) | MMEACECTSSCTSK | |
| SCHEMBL26380748 | 0.92 | MME (0.47) | MMEACECTSSCTSK | |
| SCHEMBL11969744 | 0.90 | MME (0.66) | MMEACE | |
| SCHEMBL15202178 | 0.90 | MME (0.66) | MMEACE | |
| SCHEMBL15467742 | 0.86 | MME (0.56) | MMEACE | |
| SCHEMBL19687924 | 0.86 | MME (0.56) | MMEACE | |
| SCHEMBL19687841 | 0.85 | MME (0.58) | MMEACE | |
| SCHEMBL15472630 | 0.85 | MME (0.58) | MMEACE | |
| SCHEMBL19687840 | 0.84 | MME (0.55) | MMEACE | |
| SCHEMBL15472652 | 0.84 | MME (0.58) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882716-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014025891-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2014-02-13 | — | — | WO | disclosed |