Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 19/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.68 |
| ▸ | NCOR1 | O75376 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15564604 | 1.00 | HDAC2 (0.69) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL15671113 | 0.89 | HDAC1 (0.57) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL15671116 | 0.89 | HDAC1 (0.57) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL15563942 | 0.88 | HDAC2 (0.76) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL15563938 | 0.88 | HDAC2 (0.76) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL19512462 | 0.86 | HDAC2 (0.79) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL24145574 | 0.86 | HDAC2 (0.73) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL15563769 | 0.85 | HDAC3 (0.62) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL15563774 | 0.85 | HDAC3 (0.62) | HDAC2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL19524741 | 0.84 | HDAC2 (0.77) | HDAC2HDAC3HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876928-B1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME LLC (US) | 2024-10-23 | — | — | EP | disclosed |
| US-20210403479-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2021-12-30 | — | — | US | disclosed |
| EP-3876928-A2 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | Merck Sharp & Dohme Corp. (US) | 2021-09-15 | — | — | EP | disclosed |
| EP-2882724-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S P A (IT) | 2017-11-01 | — | — | EP | disclosed |
| US-9371295-B2 | Compounds for use in the treatment of disorders that are ameliorated by inhibition of HDAC | IRBM-SCIENCE PARK S.P.A. (IT) | 2016-06-21 | — | — | US | disclosed |
| US-20150218112-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2015-08-06 | — | — | US | disclosed |
| EP-2882724-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - Science Park S.p.A. (IT) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023754-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403479-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | HDAC1, HDAC11, HDAC3 | HDAC2 4/4885HDAC3 3/4885HDAC1 1/4885 |
| US-20150218112-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | HDAC5, HDAC4, HDAC6 | HDAC2 12/4885HDAC3 7/4885HDAC1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.