Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15565002 | 1.00 | HDAC1 (0.78) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15563877 | 0.93 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15564032 | 0.89 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15564031 | 0.89 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL2073548 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15564456 | 0.88 | HDAC1 (0.60) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15564458 | 0.88 | HDAC1 (0.60) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15606556 | 0.87 | HDAC1 (0.87) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL16968865 | 0.87 | HDAC1 (0.87) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15563435 | 0.84 | HDAC2 (0.77) | HDAC1HDAC3HDAC2HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371295-B2 | Compounds for use in the treatment of disorders that are ameliorated by inhibition of HDAC | IRBM-SCIENCE PARK S.P.A. (IT) | 2016-06-21 | — | — | US | claimed |
| US-20150218112-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2015-08-06 | — | — | US | claimed |
| EP-2882724-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S P A (IT) | 2017-11-01 | — | — | EP | disclosed |
| EP-2882724-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S P A (IT) | 2017-11-01 | — | — | EP | disclosed |
| US-9371295-B2 | Compounds for use in the treatment of disorders that are ameliorated by inhibition of HDAC | IRBM-SCIENCE PARK S.P.A. (IT) | 2016-06-21 | — | — | US | disclosed |
| US-20150218112-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2015-08-06 | — | — | US | disclosed |
| EP-2882724-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - Science Park S.p.A. (IT) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023754-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218112-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | HDAC5, HDAC4, HDAC6 | HDAC1 5/4885HDAC3 7/4885HDAC2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.