Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 12/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 12/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | CDK9 | P50750 | 6/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK7 | P50613 | 12/20 | 0.46 |
| ▸ | CCNH | P51946 | 11/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15565642 | 1.00 | CCNK (0.48) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL15598388 | 1.00 | CCNK (0.48) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL24311839 | 0.88 | CCNK (0.48) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL15566082 | 0.88 | CCNK (0.48) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL15568469 | 0.86 | CCNK (0.49) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL16978989 | 0.86 | CCNK (0.49) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL15568467 | 0.86 | CCNK (0.49) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL15566724 | 0.85 | CCNK (0.40) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL15566723 | 0.85 | CCNK (0.40) | CCNKCDK12CDK2CDK9CCNT1 | |
| SCHEMBL24311767 | 0.80 | CDK7 (0.47) | CCNKCDK12CDK2CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725462-B2 | Pyridopyrimidine derivatives as protein kinase inhibitors | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | claimed |
| EP-2882746-B1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-12-07 | — | — | EP | claimed |
| US-20150218186-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | claimed |
| EP-2882746-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Merck Patent GmbH (DE) | 2015-06-17 | — | — | EP | claimed |
| WO-2014023385-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-02-13 | — | — | WO | claimed |
| US-9725462-B2 | Pyridopyrimidine derivatives as protein kinase inhibitors | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| EP-2882746-B1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-12-07 | — | — | EP | disclosed |
| US-20150218186-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218186-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | SYK, LYN, IRAK1 | CCNK 345/4885CDK12 315/4885CDK2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.