Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569138 | 0.92 | SYK (0.70) | SYK | |
| SCHEMBL15569028 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL15569715 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL15569136 | 0.81 | SYK (1.00) | SYK | |
| SCHEMBL15569127 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL15569530 | 0.79 | SYK (1.00) | SYK | |
| SCHEMBL15569961 | 0.78 | SYK (1.00) | SYK | |
| SCHEMBL15569819 | 0.77 | SYK (1.00) | SYK | |
| SCHEMBL15569690 | 0.76 | SYK (1.00) | SYK | |
| SCHEMBL16978740 | 0.76 | SYK (0.72) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | claimed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | claimed |
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |