Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 3/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13552110 | 0.80 | HCAR2 (0.44) | HCAR2POLBPSMD14MGAMKDM4E | |
| SCHEMBL28586933 | 0.73 | HCAR2 (0.41) | HCAR2POLBDYRK1BMGAMKDM4E | |
| SCHEMBL13386987 | 0.73 | HCAR2 (0.41) | HCAR2POLBPSMD14MGAMKDM4E | |
| Hydrochloric Acid SCHEMBL13386995 | 0.72 | HCAR2 (0.40) | HCAR2POLBPSMD14MGAMKDM4E | |
| SCHEMBL30967983 | 0.72 | DYRK1A (0.44) | DYRK1APSMD14KDM4E | |
| SCHEMBL9818232 | 0.71 | MAP2K4 (0.50) | DYRK1ADYRK1BKDM4EMAP2K4MAPK1 | |
| SCHEMBL31523324 | 0.71 | MAP2K4 (0.50) | DYRK1ADYRK1BKDM4EMAP2K4MAPK1 | |
| SCHEMBL30792836 | 0.69 | HCAR2 (0.50) | HCAR2POLBPSMD14MGAMKDM4E | |
| SCHEMBL487368 | 0.69 | HCAR2 (0.50) | HCAR2POLBPSMD14MGAMKDM4E | |
| SCHEMBL1759261 | 0.67 | DYRK1A (0.52) | HCAR2POLBDYRK1AMGAMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2884981-A2 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014028589-A2 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2014-02-20 | — | — | WO | disclosed |