Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.57 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599600 | 0.82 | TNKS (0.49) | TNKSPARP1PARP2HSD11B1SCN1A | |
| SCHEMBL16997531 | 0.77 | TNKS (0.57) | TNKSPARP1PARP2HSD11B1PLD1 | |
| SCHEMBL15599591 | 0.77 | TNKS (0.54) | TNKSPARP1PARP2HSD11B1PLD1 | |
| SCHEMBL16989701 | 0.77 | TNKS (0.54) | TNKSPARP1PARP2HSD11B1PLD1 | |
| SCHEMBL15599596 | 0.77 | TNKS (0.54) | TNKSPARP1PARP2HSD11B1PLD1 | |
| SCHEMBL16456354 | 0.77 | TNKS (0.54) | TNKSPARP1PARP2HSD11B1SCN1A | |
| SCHEMBL15574998 | 0.75 | CHRM4 (0.50) | TNKSPARP1PARP2HSD11B1SCN1A | |
| SCHEMBL7090704 | 0.75 | TNKS (0.45) | TNKSPARP1PARP2HSD11B1SCN1A | |
| SCHEMBL830500 | 0.75 | TNKS (0.51) | TNKSPARP1PARP2HSD11B1SCN1A | |
| SCHEMBL16989732 | 0.75 | TNKS (1.00) | TNKSPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890696-A1 | QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN, INC. (US) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014036022-A1 | QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN INC. (US) | 2014-03-06 | — | — | WO | disclosed |