Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | RAF1 | P04049 | 9/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | FRK | P42685 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | BLK | P51451 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15575227 | 0.92 | MAPK14 (0.55) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL15574712 | 0.86 | RAF1 (0.64) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL23747741 | 0.85 | RAF1 (0.62) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL13603485 | 0.84 | KDR (0.55) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL13603487 | 0.84 | RAF1 (0.60) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL13603809 | 0.84 | KDR (0.61) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL171253 | 0.84 | KMT2A (0.61) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL17000003 | 0.83 | POLB (0.58) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL15574494 | 0.82 | RAF1 (0.64) | MAPK14RAF1EPHX2KDRRET | |
| SCHEMBL13611268 | 0.82 | MAPK14 (0.59) | MAPK14RAF1EPHX2KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890380-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014032755-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-03-06 | — | — | WO | disclosed |