Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14551151 | 0.87 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484945 | 0.86 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484806 | 0.78 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484810 | 0.77 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1081347 | 0.77 | PIK3CA (0.72) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL11898263 | 0.77 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1517923 | 0.76 | PIK3CA (0.66) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL990522 | 0.76 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484844 | 0.76 | PIK3CA (0.66) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12719234 | 0.74 | PIK3CA (0.71) | PIK3CAPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673952-B2 | Benzoxepin PI3K inhibitor compounds and methods of use | F. HOFFMAN-LA ROCHE AG (CH) | 2014-03-18 | — | — | US | disclosed |