Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.88 |
| ▸ | HDAC3 | O15379 | 19/20 | 0.88 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.88 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580248 | 0.94 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| Bisthianostat SCHEMBL15580258 | 0.93 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580212 | 0.92 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580218 | 0.92 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580205 | 0.92 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580263 | 0.89 | HDAC1 (0.77) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL19114209 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580209 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL21151217 | 0.86 | HDAC1 (0.89) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL18508387 | 0.84 | HDAC1 (0.81) | HDAC1HDAC3HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766889-B2 | Aryl-2,2′-tandem bisthiazole compound and preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-09-08 | — | — | US | disclosed |
| US-20190211005-A1 | ARYL-2,2'-TANDEM BISTHIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-07-11 | — | — | US | disclosed |
| EP-2708534-B1 | THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHANGHAI THEORION PHARMACEUTICAL CO LTD (CN) | 2017-07-12 | — | — | EP | disclosed |
| US-9216962-B2 | Thiazole compounds, methods for preparation and use thereof | SHANGHAI PUYI CHEMICAL CO., LTD. (CN) | 2015-12-22 | — | — | US | disclosed |
| US-20140148600-A1 | THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF | SHANGHAI THEORION PHARMACEUTICAL CO., LTD. (CN) | 2014-05-29 | — | — | US | disclosed |
| EP-2708534-A1 | THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Puyi Chemical Co., Ltd. (CN) | 2014-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766889-B2 | Aryl-2,2′-tandem bisthiazole compound and preparation method and use thereof | HDAC2, HDAC5, HDAC1 | HDAC1 3/4885HDAC3 8/4885HDAC6 6/4885 |
| US-20140148600-A1 | THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF | HDAC5, HDAC7, HDAC1 | HDAC1 3/4885HDAC3 9/4885HDAC6 7/4885 |
| US-20190211005-A1 | ARYL-2,2'-TANDEM BISTHIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF | HDAC2, HDAC5, HDAC1 | HDAC1 3/4885HDAC3 8/4885HDAC6 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.