Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575048 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL121248 | 0.76 | TSHR (0.39) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| Hydrochloric Acid SCHEMBL119950 | 0.74 | TSHR (0.38) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL12196031 | 0.73 | NPC1 (0.39) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL18772798 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL1120478 | 0.71 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL14308133 | 0.69 | CHRNA7 (0.56) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL15222178 | 0.69 | HTR2C (0.37) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL20749289 | 0.68 | TSHR (0.55) | SMN1; SMN2TSHRGAAMEN1LMNA | |
| SCHEMBL19853249 | 0.68 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRGAAMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581374-B1 | Preparation of tetrahydropyrido[4,3-b]indole derivatives | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-03-19 | — | — | EP | disclosed |