Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474430 | 0.88 | CMA1 (0.34) | BRD4 | |
| SCHEMBL12164077 | 0.88 | CMA1 (0.34) | BRD4 | |
| SCHEMBL474551 | 0.76 | BRD4 (0.38) | BRD4 | |
| SCHEMBL12164033 | 0.76 | BRD4 (0.38) | BRD4 | |
| SCHEMBL474403 | 0.75 | PTGER4 (0.41) | — | |
| SCHEMBL12164066 | 0.75 | BRD4 (0.36) | BRD4 | |
| SCHEMBL12164064 | 0.75 | PTGER4 (0.41) | — | |
| SCHEMBL474361 | 0.75 | BRD4 (0.36) | BRD4 | |
| SCHEMBL474429 | 0.75 | CMA1 (0.34) | BRD4 | |
| SCHEMBL12164091 | 0.75 | CMA1 (0.34) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |