Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.55 |
| ▸ | STAT1 | P42224 | 2/20 | 0.52 |
| ▸ | STAT3 | P40763 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18810466 | 1.00 | S1PR3 (0.58) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL22553878 | 0.95 | SMN1; SMN2 (0.59) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL20305303 | 0.92 | SMN1; SMN2 (0.65) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL21679038 | 0.84 | SMN1; SMN2 (0.57) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL891991 | 0.84 | S1PR3 (0.55) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL21679155 | 0.82 | SMN1; SMN2 (0.56) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL892519 | 0.82 | HSD17B10 (0.53) | S1PR3RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL17619253 | 0.80 | S1PR3 (0.60) | S1PR3RAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL891863 | 0.80 | S1PR3 (0.65) | S1PR3RAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL31644564 | 0.79 | SMN1; SMN2 (0.49) | RAB9ANPC1SMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888255-B1 | HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE | UNIV TEXAS (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2014031936-A2 | HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE | JONES PHILIP (US) | 2014-02-27 | — | — | WO | disclosed |