Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.45 |
| ▸ | IL2 | P60568 | 3/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599271 | 0.94 | ALK (0.56) | ALKMAP4K1IL2MAP3K11 | |
| SCHEMBL17286298 | 0.92 | ALK (0.56) | ALKMAP4K1IL2MAP3K11TNIK | |
| SCHEMBL17273490 | 0.92 | ALK (0.57) | ALKMAP4K1IL2MAP3K11TNIK | |
| SCHEMBL15599345 | 0.91 | ALK (0.55) | ALKMAP4K1IL2MAP3K11TNIK | |
| Hydrochloric Acid SCHEMBL17273444 | 0.91 | ALK (0.56) | ALKMAP4K1IL2MAP3K11TNIK | |
| SCHEMBL15599391 | 0.91 | ALK (0.59) | ALKMAP4K1IL2TNIK | |
| SCHEMBL15599469 | 0.90 | ALK (0.69) | ALKMAP4K1IL2TNIK | |
| SCHEMBL15599468 | 0.90 | ALK (0.58) | ALKMAP4K1IL2MAP3K11TNIK | |
| SCHEMBL15599378 | 0.87 | ALK (0.56) | ALKMAP4K1IL2TNIK | |
| SCHEMBL15557168 | 0.87 | ALK (0.51) | ALKMAP4K1IL2MAP3K11TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014006554-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-01-09 | — | — | WO | disclosed |