Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tolterodine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 9/20 | 1.00 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 8/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 2/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | CX3CR1 | P49238 | 1/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 1.00 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | ESR1 | P03372 | 1/20 | 0.84 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.84 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.84 |
| ▸ | HRH2 | P25021 | 1/20 | 0.84 |
| ▸ | HTR2A | P28223 | 1/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolterodine SCHEMBL3098149 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL6472968 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL2403972 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL110955 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL467372 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL36881 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL29873356 | 1.00 | CHRM3 (1.00) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL6024199 | 0.98 | CHRM3 (0.96) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL6024194 | 0.98 | CHRM3 (0.96) | CHRM3ADRB2CHRM2CHRM1CHRM5 | |
| Tolterodine SCHEMBL1989702 | 0.93 | CHRM3 (0.88) | CHRM3ADRB2CHRM2CHRM1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017003909-A2 | CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT | CHACHISVILIS MIRIANAS (US) | 2017-01-05 | — | — | WO | disclosed |
| EP-2304425-A1 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | Dynamic Connections, Llc (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009155406-A1 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | DYNAMIC CONNECTIONS, LLC (US) | 2009-12-23 | — | — | WO | disclosed |
| EP-2134697-A2 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | Dynamic Connections, Llc (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008130980-A2 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | DYNAMIC CONNECTIONS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |