Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 20/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15603080 | 0.87 | PIK3R1 (0.63) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL5558592 | 0.86 | PIK3R1 (0.75) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL15603107 | 0.78 | PIK3CA (0.54) | PIK3R1PIK3CAPIK3CDMTOR | |
| SCHEMBL15602986 | 0.78 | PIK3R1 (0.77) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL15602991 | 0.78 | PIK3R1 (0.73) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL15602979 | 0.77 | PIK3R1 (0.66) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL15603091 | 0.76 | PIK3R1 (0.72) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL15603031 | 0.76 | PIK3R1 (0.82) | PIK3R1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5562537 | 0.75 | PIK3R1 (1.00) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB | |
| SCHEMBL15602992 | 0.75 | PIK3R1 (1.00) | PIK3R1PIK3CAPIK3CDKCNH2PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419429-B1 | IMIDAZOPYRAZINES AS INHIBITORS OF PROTEIN KINASES | CT NAC INVESTIGACIONES ONCOLOGICAS CNIO (ES) | 2014-03-26 | — | — | EP | claimed |