Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27242937 | 0.78 | MELK (0.51) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL22964274 | 0.76 | DYRK1A (0.49) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL29725390 | 0.76 | DYRK1A (0.49) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL29725419 | 0.75 | MELK (0.47) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL22964272 | 0.75 | MELK (0.47) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL28731613 | 0.74 | MELK (0.50) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL27242897 | 0.74 | MELK (0.50) | MELKDYRK1AMTORPIK3CAROCK2 | |
| SCHEMBL22964134 | 0.74 | DYRK1A (0.51) | MELKDYRK1A | |
| SCHEMBL31013179 | 0.74 | DYRK1A (0.51) | MELKDYRK1A | |
| SCHEMBL29725602 | 0.74 | DYRK1A (0.51) | MELKDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014040373-A1 | PI3K AND/OR MTOR INHIBITOR | 山东轩竹医药科技有限公司 (CN) | 2014-03-20 | — | — | WO | disclosed |