Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK3 | O75914 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CCND1 | P24385 | 3/20 | 0.36 |
| ▸ | CCND3 | P30281 | 3/20 | 0.36 |
| ▸ | CCND2 | P30279 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041558 | 0.93 | FGFR1 (0.41) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15036294 | 0.88 | FGFR1 (0.40) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15258258 | 0.81 | PAK3 (0.50) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15036256 | 0.80 | FGFR1 (0.42) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15036319 | 0.78 | FGFR1 (0.39) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15036460 | 0.76 | FGFR1 (0.46) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15617458 | 0.76 | FGFR1 (0.41) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15034980 | 0.76 | WEE1 (0.45) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15035881 | 0.75 | WEE1 (0.43) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15034795 | 0.74 | WEE1 (0.43) | PAK3PAK4LIMK1LIMK2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680099-B2 | 6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-03-25 | — | — | US | disclosed |