Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.35 |
| ▸ | CDK2 | P24941 | 10/20 | 0.35 |
| ▸ | CCND1 | P24385 | 9/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036434 | 0.91 | WEE1 (0.36) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15258291 | 0.81 | PAK4 (0.38) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15618073 | 0.81 | CCNE1 (0.41) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15618079 | 0.76 | CDK1 (0.38) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15617477 | 0.76 | CCNE1 (0.41) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15258244 | 0.76 | CDK2 (0.37) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15258283 | 0.76 | JAK3 (0.35) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15617468 | 0.76 | JAK3 (0.37) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15258286 | 0.74 | CDK4 (0.39) | CCNE1CDK2CCND1CDK6FGFR1 | |
| SCHEMBL15618067 | 0.74 | TNK2 (0.36) | CCNE1CDK2CCND1CDK6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680099-B2 | 6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8680099-B2 | 6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-03-25 | — | — | US | disclosed |