Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 18/20 | 1.00 |
| ▸ | NOTCH3 | Q9UM47 | 17/20 | 1.00 |
| ▸ | NOTCH2 | Q04721 | 1/20 | 1.00 |
| ▸ | NOTCH4 | Q99466 | 1/20 | 1.00 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.64 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.64 |
| ▸ | CCKBR | P32239 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15622117 | 1.00 | NOTCH1 (1.00) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| SCHEMBL15622692 | 0.95 | NOTCH1 (1.00) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| SCHEMBL15622141 | 0.94 | NOTCH1 (0.89) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| SCHEMBL15622116 | 0.94 | NOTCH1 (0.89) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| SCHEMBL15621981 | 0.94 | NOTCH1 (0.89) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| SCHEMBL15622436 | 0.94 | NOTCH1 (0.89) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| Osugacestat SCHEMBL12543868 | 0.91 | NOTCH1 (0.84) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| Osugacestat SCHEMBL21577519 | 0.91 | NOTCH1 (0.84) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| Osugacestat SCHEMBL29412689 | 0.91 | NOTCH1 (0.84) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 | |
| Osugacestat SCHEMBL17420836 | 0.91 | NOTCH1 (0.84) | NOTCH1NOTCH3NOTCH2NOTCH4PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897954-A1 | FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2015-07-29 | — | — | EP | disclosed |
| WO-2014047392-A1 | FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-27 | — | — | WO | disclosed |