Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 16/20 | 1.00 |
| ▸ | BCL2 | P10415 | 4/20 | 0.68 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.68 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15622745 | 0.98 | MCL1 (0.96) | MCL1BCL2BCL2L1GPR17ALB | |
| SCHEMBL15622386 | 0.89 | MCL1 (0.80) | MCL1BCL2BCL2L1 | |
| SCHEMBL15623020 | 0.87 | MCL1 (0.77) | MCL1BCL2BCL2L1 | |
| SCHEMBL2207431 | 0.87 | MCL1 (1.00) | MCL1BCL2ALB | |
| SCHEMBL15625803 | 0.86 | MCL1 (1.00) | MCL1 | |
| SCHEMBL15622406 | 0.85 | MCL1 (0.96) | MCL1BCL2ALB | |
| SCHEMBL17270289 | 0.84 | MCL1 (1.00) | MCL1 | |
| SCHEMBL29928296 | 0.81 | MCL1 (1.00) | MCL1BCL2BCL2L1ALB | |
| SCHEMBL15622980 | 0.80 | MCL1 (0.76) | MCL1BCL2BCL2L1GPR17ALB | |
| SCHEMBL29927640 | 0.79 | MCL1 (0.83) | MCL1BCL2BCL2L1GPR17ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844032-B2 | Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20180312485-A1 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2018-11-01 | — | — | US | disclosed |
| US-10093640-B2 | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2018-10-09 | — | — | US | disclosed |
| US-20150336925-A1 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2015-11-26 | — | — | US | disclosed |
| WO-2014047427-A2 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2014-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312485-A1 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCLAF1 | MCL1 1/4885BCL2 5/4885BCL2L1 2/4885 |
| US-20150336925-A1 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCLAF1 | MCL1 1/4885BCL2 5/4885BCL2L1 2/4885 |
| US-10093640-B2 | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors | MCL1, BCL2L1, BCLAF1 | MCL1 1/4885BCL2 5/4885BCL2L1 2/4885 |
| US-10844032-B2 | Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors | MCL1, BCL2L1, BCLAF1 | MCL1 1/4885BCL2 5/4885BCL2L1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.