Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 7/20 | 1.00 |
| ▸ | EGFR | P00533 | 4/20 | 1.00 |
| ▸ | PDGFRA | P16234 | 2/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 13/20 | 0.75 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.75 |
| ▸ | FLT3 | P36888 | 3/20 | 0.70 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
| ▸ | PLK4 | O00444 | 2/20 | 0.70 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.70 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.70 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.70 |
| ▸ | INSR | P06213 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009123 | 0.93 | KDR (0.86) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL31726680 | 0.90 | KDR (0.81) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL7009069 | 0.88 | KDR (0.79) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL7097360 | 0.87 | KDR (0.77) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL7096348 | 0.86 | KDR (0.75) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL16090333 | 0.86 | KDR (0.77) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL29856874 | 0.85 | KDR (1.00) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL20226048 | 0.85 | KDR (1.00) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL2114999 | 0.85 | KDR (1.00) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL31727530 | 0.85 | KDR (0.74) | KDRPDGFRBEGFRPDGFRAPRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675274-B1 | SORAFENIB DERIVATIVES AS sEH INHIBITORS | UNIV CALIFORNIA (US) | 2017-05-03 | — | — | EP | disclosed |
| US-9029401-B2 | Sorafenib derivatives as sEH inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140088156-A1 | SORAFENIB DERIVATIVES AS SEH INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088156-A1 | SORAFENIB DERIVATIVES AS SEH INHIBITORS | EPHX1, FAH, EPHX2 | KDR 53/4885PDGFRB 608/4885EGFR 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.