Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.69 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224398 | 0.85 | CHEK1 (0.59) | CHEK1CDK2AP1 | |
| SCHEMBL1563747 | 0.82 | CHEK1 (1.00) | CHEK1CDK2AP1 | |
| SCHEMBL1564190 | 0.78 | CHEK1 (1.00) | CHEK1CDK2AP1 | |
| SCHEMBL1565116 | 0.77 | CHEK1 (1.00) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL1564743 | 0.77 | CHEK1 (1.00) | CHEK1CDK2AP1MAP4K4IKBKBJAK2 | |
| SCHEMBL1563539 | 0.77 | CHEK1 (0.53) | CHEK1CDK2AP1MAP4K4IKBKBJAK2 | |
| SCHEMBL1564746 | 0.75 | CHEK1 (1.00) | CHEK1CDK2AP1MAP4K4IKBKBJAK2 | |
| SCHEMBL1564586 | 0.75 | CHEK1 (1.00) | CHEK1CDK2AP1MAP4K4IKBKBJAK2 | |
| SCHEMBL1562811 | 0.75 | CHEK1 (1.00) | CHEK1CDK2AP1 | |
| SCHEMBL27769058 | 0.75 | CHEK1 (1.00) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |