Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 1.00 |
| ▸ | MELK | Q14680 | 3/20 | 0.84 |
| ▸ | PLK4 | O00444 | 1/20 | 0.84 |
| ▸ | GAK | O14976 | 1/20 | 0.84 |
| ▸ | JAK2 | O60674 | 1/20 | 0.84 |
| ▸ | ULK1 | O75385 | 1/20 | 0.84 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.84 |
| ▸ | STK10 | O94804 | 1/20 | 0.84 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.84 |
| ▸ | PAK4 | O96013 | 1/20 | 0.84 |
| ▸ | ABL1 | P00519 | 1/20 | 0.84 |
| ▸ | EGFR | P00533 | 1/20 | 0.84 |
| ▸ | LCK | P06239 | 1/20 | 0.84 |
| ▸ | FYN | P06241 | 1/20 | 0.84 |
| ▸ | FES | P07332 | 1/20 | 0.84 |
| ▸ | YES1 | P07947 | 1/20 | 0.84 |
| ▸ | LYN | P07948 | 1/20 | 0.84 |
| ▸ | RET | P07949 | 1/20 | 0.84 |
| ▸ | HCK | P08631 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532554 | 0.95 | CHEK1 (0.90) | CHEK1MELKPLK4GAKJAK2 | |
| Azd-7762 SCHEMBL15105420 | 0.92 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| Azd-7762 SCHEMBL1127614 | 0.92 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| Azd-7762 SCHEMBL29388936 | 0.92 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| Azd-7762 SCHEMBL1564574 | 0.92 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| Azd-7762 SCHEMBL31517325 | 0.92 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532506 | 0.91 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL1562895 | 0.91 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL1564888 | 0.91 | CHEK1 (1.00) | CHEK1MELKPLK4GAKJAK2 | |
| Azd-7762 SCHEMBL19457662 | 0.91 | MELK (1.00) | CHEK1MELKPLK4GAKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |