Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.79 |
| ▸ | JAK3 | P52333 | 6/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
| ▸ | JAK1 | P23458 | 3/20 | 0.58 |
| ▸ | TTK | P33981 | 2/20 | 0.58 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813134 | 0.89 | BTK (1.00) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL17071433 | 0.86 | BTK (0.85) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL15640174 | 0.86 | BTK (0.89) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL17071407 | 0.85 | BTK (0.88) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL15638700 | 0.85 | BTK (1.00) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL17071396 | 0.84 | BTK (0.88) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL12813112 | 0.84 | BTK (1.00) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL16144739 | 0.83 | BTK (0.80) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL17071435 | 0.82 | BTK (0.78) | BTKJAK3JAK2JAK1TTK | |
| SCHEMBL17359395 | 0.81 | BTK (0.78) | BTKJAK3JAK2JAK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903971-B1 | SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-2903971-A2 | SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS | University Of Utah Research Foundation (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014055934-A2 | SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-04-10 | — | — | WO | disclosed |