Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15640366 | 1.00 | PTGDR (0.42) | PTGDRITGB3ITGAVPOLBTYK2 | |
| SCHEMBL15640365 | 1.00 | PTGDR (0.42) | PTGDRITGB3ITGAVPOLBTYK2 | |
| SCHEMBL517705 | 0.90 | NR1H2 (0.44) | NR1H2 | |
| SCHEMBL517704 | 0.90 | NR1H2 (0.44) | NR1H2 | |
| SCHEMBL15640282 | 0.87 | PTGDR (0.48) | PTGDRPOLBTYK2CCR5NR1H2 | |
| SCHEMBL15640283 | 0.87 | PTGDR (0.48) | PTGDRPOLBTYK2CCR5NR1H2 | |
| SCHEMBL517056 | 0.85 | NR1H2 (0.41) | PTGDRPOLBTYK2NR1H2MTNR1A | |
| SCHEMBL517055 | 0.85 | NR1H2 (0.41) | PTGDRPOLBTYK2NR1H2MTNR1A | |
| SCHEMBL15640459 | 0.85 | PTGDR (0.46) | PTGDRPOLBTYK2CCR5NR1H2 | |
| SCHEMBL15640458 | 0.85 | PTGDR (0.46) | PTGDRPOLBTYK2CCR5NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598486-B1 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS | NOVARTIS AG (CH) | 2017-06-28 | — | — | EP | claimed |
| US-8697739-B2 | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof | NOVARTIS AG (CH) | 2014-04-15 | — | — | US | claimed |
| EP-2598486-B1 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS | NOVARTIS AG (CH) | 2017-06-28 | — | — | EP | disclosed |