Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.53 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.50 |
| ▸ | MELK | Q14680 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532576 | 0.91 | USP30 (0.52) | USP30CNR1CNR2CHEK1MELK | |
| SCHEMBL31532583 | 0.91 | USP30 (0.52) | USP30CNR1CNR2CHEK1MELK | |
| SCHEMBL31532608 | 0.90 | USP30 (0.56) | USP30CNR1CNR2CHEK1MELK | |
| SCHEMBL31532687 | 0.89 | CHEK1 (0.62) | USP30CHEK1MELKPLK4GAK | |
| SCHEMBL31532635 | 0.89 | USP30 (0.58) | USP30CHEK1MELKPLK4GAK | |
| SCHEMBL12649363 | 0.89 | CHEK1 (0.62) | USP30CHEK1MELKPLK4GAK | |
| SCHEMBL31532629 | 0.89 | USP30 (0.58) | USP30CHEK1MELKPLK4GAK | |
| SCHEMBL31532526 | 0.89 | USP30 (0.58) | USP30CHEK1MELKPLK4GAK | |
| SCHEMBL31532594 | 0.88 | USP30 (0.51) | USP30CHEK1MELKPLK4GAK | |
| SCHEMBL1564849 | 0.88 | CNR1 (0.57) | USP30CNR1CNR2ANO1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| CN-1922172-A | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | CN | disclosed |