Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.84 |
| ▸ | TYK2 | P29597 | 2/20 | 0.84 |
| ▸ | JAK1 | P23458 | 11/20 | 0.73 |
| ▸ | JAK3 | P52333 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2243221 | 0.92 | JAK2 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2238494 | 0.91 | JAK2 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2238445 | 0.84 | JAK1 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2241762 | 0.84 | JAK2 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2238034 | 0.84 | JAK2 (0.85) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2237211 | 0.83 | JAK1 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2237921 | 0.83 | JAK2 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2760293 | 0.83 | JAK2 (0.83) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2237152 | 0.83 | JAK2 (1.00) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL2238754 | 0.83 | JAK2 (1.00) | JAK2TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361251-B1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2014-04-30 | — | — | EP | claimed |