Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210397 | 0.89 | MAPT (0.52) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL15663416 | 0.88 | AURKA (0.45) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL15663394 | 0.87 | MAPT (0.47) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL2975192 | 0.87 | MAPT (0.47) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL15663908 | 0.87 | FGFR2 (0.44) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL2209719 | 0.86 | MAPT (0.48) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL15663575 | 0.86 | FGFR2 (0.43) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL2979377 | 0.85 | AURKA (0.40) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL2204168 | 0.85 | MAPT (0.53) | FGFR2AURKAAURKBTPX2MAPT | |
| SCHEMBL2209836 | 0.85 | MAPT (0.58) | FGFR2AURKAAURKBTPX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |