Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1567228 | 0.85 | SMN1; SMN2 (0.68) | NR1H4HDAC2HDAC8HDAC6EPHX2 | |
| SCHEMBL7322242 | 0.85 | NR1H4 (1.00) | NR1H4HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL1695082 | 0.80 | NR1H4 (0.58) | NR1H4HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL1565797 | 0.80 | NR1H4 (0.71) | NR1H4HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL27942197 | 0.80 | NPC1 (0.64) | NR1H4KMT2AIDO1SMN1; SMN2HTT | |
| SCHEMBL27920877 | 0.80 | NR1H4 (0.70) | NR1H4HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL7077351 | 0.79 | MRGPRX4 (0.74) | NR1H4HDAC6KMT2AMRGPRX4HTT | |
| SCHEMBL9787292 | 0.78 | LSS (0.70) | NR1H4KMT2ASMN1; SMN2MRGPRX4HTT | |
| SCHEMBL14894197 | 0.76 | NR1H4 (0.85) | NR1H4HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL6194769 | 0.76 | NR1H4 (0.78) | NR1H4HDAC3HDAC1HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889876-B2 | Histone deacetylase inhibitors and uses thereof | JIANGSU HENGYI PHARMACEUTICAL CO., LTD. (CN) | 2014-11-18 | — | — | US | disclosed |
| CN-101633638-B | Class I histone deacetylase inhibitor and application thereof | JIANGSU GOWORTH INVEST CO LTD | 2012-07-25 | — | — | CN | disclosed |
| US-20110152323-A1 | Histone deacetylase inhibitors and uses thereof | JIANGSU GOWORTH INVESTMENT CO. LTD (CN) | 2011-06-23 | — | — | US | disclosed |
| EP-2308868-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | Jiangsu Goworth Investment Co. Ltd (CN) | 2011-04-13 | — | — | EP | disclosed |
| CN-101633638-A | Class I histone deacetylase inhibitor and application thereof | JIANGSU GOWORTH INVEST CO LTD | 2010-01-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152323-A1 | Histone deacetylase inhibitors and uses thereof | HDAC1, HDAC11, HDAC5 | NR1H4 1322/4885HDAC3 9/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.