Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15663626 | 0.91 | KDR (0.39) | KDRPDGFRAHTTMAPTYES1 | |
| SCHEMBL2209181 | 0.91 | KDR (0.41) | KDRPDGFRAHTTMAPTYES1 | |
| SCHEMBL15663700 | 0.89 | KDR (0.39) | KDRPDGFRAGRM4HTTMAPT | |
| SCHEMBL15663472 | 0.88 | KDR (0.37) | KDRPDGFRAHTTMAPTYES1 | |
| SCHEMBL15663325 | 0.88 | MAPT (0.48) | KDRHTTMAPTLMNAMEN1 | |
| SCHEMBL15663426 | 0.87 | KDR (0.38) | KDRPDGFRAHTTMAPTYES1 | |
| SCHEMBL2208817 | 0.87 | KDR (0.39) | KDRPDGFRAHTTMAPTYES1 | |
| SCHEMBL15663393 | 0.86 | MAPT (0.41) | KDRHTTMAPTLMNAMEN1 | |
| SCHEMBL2206890 | 0.85 | KDR (0.41) | KDRPDGFRAHTTMAPTYES1 | |
| SCHEMBL2208866 | 0.84 | CYP1A2 (0.36) | KDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |