Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 5/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 3/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207029 | 0.93 | FGFR2 (0.72) | FGFR2PDGFRAKDRKITEGFR | |
| SCHEMBL2207343 | 0.90 | FGFR2 (0.63) | FGFR2PDGFRAKDRMETKIT | |
| SCHEMBL2208900 | 0.87 | FGFR2 (0.63) | FGFR2PDGFRAKDRKITAXL | |
| SCHEMBL14047121 | 0.86 | FGFR2 (0.62) | FGFR2PDGFRAKDRKITRET | |
| SCHEMBL2208407 | 0.84 | FGFR2 (0.71) | FGFR2PDGFRAKDRKIT | |
| SCHEMBL2210992 | 0.84 | FGFR2 (0.58) | FGFR2KDREGFRLMNAMAPT | |
| SCHEMBL2211767 | 0.84 | FGFR2 (0.58) | FGFR2KDREGFRLMNAMAPT | |
| SCHEMBL2210071 | 0.84 | FGFR2 (0.59) | FGFR2PDGFRAKDRMETKIT | |
| SCHEMBL2210388 | 0.83 | FGFR2 (0.63) | FGFR2PDGFRAKDRKITAXL | |
| SCHEMBL4486596 | 0.82 | FGFR2 (0.81) | FGFR2PDGFRAKDRMETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |