Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 14/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.42 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402054 | 0.93 | TNK2 (0.59) | TNK2IGF1RFGFR2 | |
| SCHEMBL401909 | 0.93 | TNK2 (0.59) | TNK2IGF1RFGFR2 | |
| SCHEMBL402101 | 0.93 | TNK2 (0.46) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL400470 | 0.93 | TNK2 (0.46) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL2797385 | 0.90 | TNK2 (0.52) | TNK2IGF1RFGFR2 | |
| SCHEMBL1566724 | 0.85 | TNK2 (0.41) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL401216 | 0.83 | TNK2 (0.58) | TNK2IGF1R | |
| SCHEMBL4541532 | 0.83 | TNK2 (0.58) | TNK2IGF1R | |
| SCHEMBL10226172 | 0.83 | TNK2 (0.58) | TNK2IGF1R | |
| SCHEMBL400530 | 0.83 | TNK2 (0.45) | TNK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305682-A1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |